CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.40
Functional Family Probable tRNA N6-adenosine threonylcarbamoyltransferase

Enzyme Information

2.3.1.234
N(6)-L-threonylcarbamoyladenine synthase.
based on mapping to UniProt Q58530
L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L- threonylcarbamoyladenine(37) in tRNA.
-!- The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg). -!- Formerly EC 2.6.99.4.
2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q58530
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q57646
CG121_METJA
Methanocaldococcus jannaschii DSM 2661
Regulatory protein Cgi121

PDB Structure

PDB 3ENH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine
Mao, D.Y.L., Neculai, D., Downey, M., Orlicky, S., Haffani, Y.Z., Ceccarelli, D.F., Ho, J.S.L., Szilard, R.K., Zhang, W., Ho, C.S., Wan, L., Fares, C., Rumpel, S., Kurinov, I., Arrowsmith, C.H., Durocher, D., Sicheri, F.
Mol.Cell