CATH Classification

Domain Context

CATH Clusters

Superfamily 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Functional Family 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Enzyme Information

4.6.1.12
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
based on mapping to UniProt P62617
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl- D-erythritol 2,4-cyclodiphosphate + CMP.
-!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

P62617
ISPF_ECOLI
Escherichia coli K-12
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

PDB Structure

PDB 3ELC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
Ramsden, N.L., Buetow, L., Dawson, A., Kemp, L.A., Ulaganathan, V., Brenk, R., Klebe, G., Hunter, W.N.
J.Med.Chem.