CATH Classification

Domain Context

CATH Clusters

Superfamily Acetylglutamate kinase-like
Functional Family Uridylate kinase

Enzyme Information

2.7.4.22
UMP kinase.
based on mapping to UniProt P59009
ATP + UMP = ADP + UDP.
-!- Strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme EC 2.7.4.14 for the same purpose. -!- Subject of feedback regulation, being inhibited by UTP and activated by GTP.

UniProtKB Entries (1)

P59009
PYRH_XANCP
Xanthomonas campestris pv. campestris str. ATCC 33913
Uridylate kinase

PDB Structure

PDB 3EK6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Unique GTP-Binding Pocket and Allostery of Uridylate Kinase from a Gram-Negative Phytopathogenic Bacterium
Tu, J.-L., Chin, K.-H., Wang, A.H.-J., Chou, S.-H.
J.Mol.Biol.