CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase 1-1

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P20432
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
4.5.1.1
DDT-dehydrochlorinase.
based on mapping to UniProt P20432
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2- bis(4-chlorophenyl)ethylene + chloride.

UniProtKB Entries (1)

P20432
GSTD1_DROME
Drosophila melanogaster
Glutathione S-transferase D1

PDB Structure

PDB 3EIN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Probing insect detoxification systems
Feil, S.C., Low, W.Y., Ng, H.L., Pyke, J., Gooley, P., Parker, M.W., Robin, C., McConville, M., Batterham, P.
To be Published