CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P24941
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24941
CDK2_HUMAN
Homo sapiens
Cyclin-dependent kinase 2

PDB Structure

PDB 3EID
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.
Stevens, K.L., Reno, M.J., Alberti, J.B., Price, D.J., Kane-Carson, L.S., Knick, V.B., Shewchuk, L.M., Hassell, A.M., Veal, J.M., Davis, S.T., Griffin, R.J., Peel, M.R.
Bioorg.Med.Chem.Lett.