CATH Domain 3egtA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family	Farnesyl pyrophosphate synthase

Enzyme Information

UniProtKB Entries (1)

Q86C09_9TRYP

Trypanosoma brucei

Farnesyl pyrophosphate synthase

PDB Structure

PDB	3EGT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. Zhang, Y., Cao, R., Yin, F., Hudock, M.P., Guo, R.T., Krysiak, K., Mukherjee, S., Gao, Y.G., Robinson, H., Song, Y., No, J.H., Bergan, K., Leon, A., Cass, L., Goddard, A., Chang, T.K., Lin, F.Y., Van Beek, E., Papapoulos, S., Wang, A.H., Kubo, T., Ochi, M., Mukkamala, D., Oldfield, E. J.Am.Chem.Soc.