CATH Classification

Domain Context

CATH Clusters

Superfamily 2.70.98.10
Functional Family

Enzyme Information

3.2.1.97
Endo-alpha-N-acetylgalactosaminidase.
based on mapping to UniProt Q8DR60
Beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-L- serine/L-threonine-[protein] + H(2)O = beta-D-galactosyl-(1->3)-N-acetyl- alpha-D-galactosamine + L-serine/L-threonine-[protein].
-!- The enzyme catalyzes the liberation of Gal-(1->3)-beta-GalNAc alpha- linked to serine or threonine residues of mucin-type glycoproteins. -!- EngBF from Bifidobacterium longum specifically acts on core 1-type O-glycan to release the disaccharide Gal-(1->3)-beta-GalNAc. -!- The enzymes from Clostridium perfringens, Enterococcus faecalis, Propionibacterium acnes and Alcaligenes faecalis show broader specificity (e.g. release of the core 2 trisaccharide Gal-(1->3)- beta-(GlcNAc-(1->6)-beta)-GalNAc or the core 3 disaccharide GlcNAc- (1->3)-beta-GalNAc). -!- The enzyme may play an important role in the degradation and utilization of mucins having core 1 O-glycan. -!- Formerly EC 3.2.1.110.

UniProtKB Entries (1)

Q8DR60
GH101_STRR6
Streptococcus pneumoniae R6
Endo-alpha-N-acetylgalactosaminidase

PDB Structure

PDB 3ECQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structural basis for T-antigen hydrolysis by Streptococcus pneumoniae: a target for structure-based vaccine design.
Caines, M.E., Zhu, H., Vuckovic, M., Willis, L.M., Withers, S.G., Wakarchuk, W.W., Strynadka, N.C.
J.Biol.Chem.