CATH Classification

Domain Context

CATH Clusters

Superfamily 2.70.98.70
Functional Family Heparin and heparin-sulfate lyase

Enzyme Information

4.2.2.8
Heparin-sulfate lyase.
based on mapping to UniProt C6XZB6
Elimination of sulfate, appears to act on linkages between N-acetyl-D- glucosamine and uronate. Product is an unsaturated sugar.
-!- Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.
4.2.2.7
Heparin lyase.
based on mapping to UniProt C6XZB6
Eliminative cleavage of polysaccharides containing (1->4)-linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non- reducing ends.

UniProtKB Entries (1)

C6XZB6
HEPB_PEDHD
Pedobacter heparinus DSM 2366
Heparin and heparin-sulfate lyase

PDB Structure

PDB 3E7J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Catalytic mechanism of heparinase II investigated by site-directed mutagenesis and the crystal structure with its substrate.
Shaya, D., Zhao, W., Garron, M.L., Xiao, Z., Cui, Q., Zhang, Z., Sulea, T., Linhardt, R.J., Cygler, M.
J.Biol.Chem.