CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Papain

Enzyme Information

3.4.22.2
Papain.
based on mapping to UniProt P00784
Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'.
-!- From latex of the papaya (Carica papaya). -!- Inhibited by compound E-64 and proteins of the cystatin family. -!- Belongs to peptidase family C1. -!- Formerly EC 3.4.4.10.

UniProtKB Entries (2)

P00784
PAPA1_CARPA
Carica papaya
Papain
Q966X9
CHAG_TRYCR
Trypanosoma cruzi
Chagasin

PDB Structure

PDB 3E1Z
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases.
Redzynia, I., Ljunggren, A., Bujacz, A., Abrahamson, M., Jaskolski, M., Bujacz, G.
Febs J.