CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.58.480
Functional Family Tryptophan 2,3-dioxygenase

Enzyme Information

1.13.11.11
Tryptophan 2,3-dioxygenase.
based on mapping to UniProt Q8PDA8
L-tryptophan + O(2) = N-formyl-L-kynurenine.
-!- Catalyzes, together with EC 1.13.11.52, the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism. -!- Specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan. -!- Formerly EC 1.11.1.4 and EC 1.13.1.12.

UniProtKB Entries (1)

Q8PDA8
T23O_XANCP
Xanthomonas campestris pv. campestris str. ATCC 33913
Tryptophan 2,3-dioxygenase

PDB Structure

PDB 3E08
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding
Thackray, S.J., Bruckmann, C., Anderson, J.L., Campbell, L.P., Xiao, R., Zhao, L., Mowat, C.G., Forouhar, F., Tong, L., Chapman, S.K.
Biochemistry