1 keywords

CATH Domain 3dysA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1300 Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
Homologous Superfamily 1.10.1300.10 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase 9A

Enzyme Information

3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt O76083
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

O76083
PDE9A_HUMAN
Homo sapiens
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

PDB Structure

PDB 3DYS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the catalytic mechanism of human phosphodiesterase 9.
Liu, S., Mansour, M.N., Dillman, K.S., Perez, J.R., Danley, D.E., Aeed, P.A., Simons, S.P., Lemotte, P.K., Menniti, F.S.
Proc.Natl.Acad.Sci.Usa