CATH Classification

Domain Context

CATH Clusters

Superfamily RNA polymerase, RBP11-like subunit
Functional Family DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q5SHR6
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q8RQE7
RPOZ_THET8
Thermus thermophilus HB8
DNA-directed RNA polymerase subunit omega

PDB Structure

PDB 3DXJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The RNA polymerase "switch region" is a target for inhibitors.
Mukhopadhyay, J., Das, K., Ismail, S., Koppstein, D., Jang, M., Hudson, B., Sarafianos, S., Tuske, S., Patel, J., Jansen, R., Irschik, H., Arnold, E., Ebright, R.H.
Cell(Cambridge,Mass.)