CATH Classification

Domain Context

CATH Clusters

Superfamily Protein prenylyltransferase
Functional Family Geranylgeranyl transferase type-2 subunit alpha

Enzyme Information
Protein geranylgeranyltransferase type II.
based on mapping to UniProt Q08602
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl- protein + diphosphate.
-!- This enzyme, along with EC and EC, constitutes the protein prenyltransferase family of enzymes. -!- Attaches geranylgeranyl groups to two C-terminal cysteines in Ras- related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. -!- Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). -!- Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.

UniProtKB Entries (1)

Rattus norvegicus
Geranylgeranyl transferase type-2 subunit alpha

PDB Structure

External Links
Primary Citation
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
Guo, Z., Wu, Y.-W., Das, D., Delon, C., Cramer, J., Yu, S., Thuns, S., Lupilova, N., Waldmann, H., Brunsveld, L., Goody, R.S., Alexandrov, K., Blankenfeldt, W.
Embo J.