CATH Classification

Domain Context

CATH Clusters

Superfamily Protein prenylyltransferase
Functional Family Geranylgeranyl transferase type-2 subunit alpha

Enzyme Information

2.5.1.60
Protein geranylgeranyltransferase type II.
based on mapping to UniProt Q08602
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl- protein + diphosphate.
-!- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the protein prenyltransferase family of enzymes. -!- Attaches geranylgeranyl groups to two C-terminal cysteines in Ras- related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. -!- Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). -!- Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.

UniProtKB Entries (1)

Q08602
PGTA_RAT
Rattus norvegicus
Geranylgeranyl transferase type-2 subunit alpha

PDB Structure

PDB 3DSS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
Guo, Z., Wu, Y.-W., Das, D., Delon, C., Cramer, J., Yu, S., Thuns, S., Lupilova, N., Waldmann, H., Brunsveld, L., Goody, R.S., Alexandrov, K., Blankenfeldt, W.
Embo J.