CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Pyridoxal phosphate-dependent aminotransferase

Enzyme Information

2.6.1.102
GDP-perosamine synthase.
based on mapping to UniProt Q9A9H3
GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate = GDP-4-dehydro- 6-deoxy-alpha-D-mannose + L-glutamate.
-!- D-perosamine is one of several dideoxy sugars found in the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. -!- The enzyme catalyzes the final step in GDP-perosamine synthesis.

UniProtKB Entries (1)

Q9A9H3
GDPPS_CAUVC
Caulobacter vibrioides CB15
GDP-perosamine synthase

PDB Structure

PDB 3DR7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase
Cook, P.D., Carney, A.E., Holden, H.M.
Biochemistry