CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Putative oxidoreductase GLYR1 homolog |
Enzyme Information
| 1.1.1.n11 |
Succinic semialdehyde reductase.
based on mapping to UniProt Q9LSV0
4-hydroxybutanoate + NADP(+) = succinate semialdehyde + NADPH.
|
| 1.1.1.79 |
Glyoxylate reductase (NADP(+)).
based on mapping to UniProt Q9LSV0
Glycolate + NADP(+) = glyoxylate + NADPH.
-!- Also reduces hydroxypyruvate to glycerate. -!- Has some affinity for NAD(+).
|
UniProtKB Entries (1)
| Q9LSV0 |
GLYR1_ARATH
Arabidopsis thaliana
Glyoxylate/succinic semialdehyde reductase 1
|
PDB Structure
| PDB | 3DOJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Cytosolic NADPH-dependent Glyoxylate Reductase from Arabidopsis: Crystal Structure and Kinetic Characterization of Active Site Mutants
To be Published
|