CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P00517
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P00517
KAPCA_BOVIN
Bos taurus
CAMP-dependent protein kinase catalytic subunit alpha

PDB Structure

PDB 3DNE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallography-independent determination of ligand binding modes
Orts, J., Tuma, J., Reese, M., Grimm, S.K., Monecke, P., Bartoschek, S., Schiffer, A., Wendt, K.U., Griesinger, C., Carlomagno, T.
Angew.Chem.Int.Ed.Engl.