CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaconate Coenzyme A-transferase
Functional Family Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial

Enzyme Information

2.8.3.5
3-oxoacid CoA-transferase.
based on mapping to UniProt P55809
Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.
-!- Acetoacetate or, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptor. -!- Malonyl-CoA can act instead of succinyl-CoA.

UniProtKB Entries (1)

P55809
SCOT1_HUMAN
Homo sapiens
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

PDB Structure

PDB 3DLX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human 3-oxoacid CoA transferase 1.
Kavanagh, K.L., Shafqat, N., Yue, W.W., Picaud, S., Murray, J.W., Maclean, E.M., von Delft, F., Roos, A.K., Arrowsmith, C.H., Wikstrom, M., Edwards, A.M., Bountra, C., Oppermann, U.
To be Published