CATH Domain 3dljA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.630	Aminopeptidase
	3.40.630.10	Zn peptidases

Domain Context

CATH Clusters

Superfamily	Zn peptidases
Functional Family	Cytosolic non-specific dipeptidase

Enzyme Information

3.4.13.20

Beta-Ala-His dipeptidase.

based on mapping to UniProt Q96KN2

Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine.

-!- Present in the serum of humans and higher primates, but not in the serum of other mammals. -!- Activated by Cd(2+) and citrate. -!- Belongs to peptidase family M20. -!- Formerly EC 3.4.3.3, EC 3.4.13.3 and EC 3.4.13.13.

UniProtKB Entries (1)

Q96KN2

CNDP1_HUMAN

Homo sapiens

Beta-Ala-His dipeptidase

PDB Structure

PDB	3DLJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of human carnosine dipeptidase 1. Dobrovetsky, E., Dong, A., Seitova, A., He, H., Tempel, W., Kozieradzki, I., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Bochkarev, A., Cossar, D. To be Published