CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Bifunctional dihydrofolate reductase-thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P13922
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P13922
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P13922
DRTS_PLAFK
Plasmodium falciparum K1
Bifunctional dihydrofolate reductase-thymidylate synthase

PDB Structure

PDB 3DGA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria.
Dasgupta, T., Chitnumsub, P., Kamchonwongpaisan, S., Maneeruttanarungroj, C., Nichols, S.E., Lyons, T.M., Tirado-Rives, J., Jorgensen, W.L., Yuthavong, Y., Anderson, K.S.
Acs Chem.Biol.