CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Calpain-1 catalytic subunit

Enzyme Information

3.4.22.53
Calpain-2.
based on mapping to UniProt Q07009
Broad endopeptidase specificity.
-!- Cytosolic in animal cells. -!- The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52. -!- Belongs to peptidase family C2. -!- Formerly EC 3.4.22.17 and EC 3.4.24.5.

UniProtKB Entries (1)

Q07009
CAN2_RAT
Rattus norvegicus
Calpain-2 catalytic subunit

PDB Structure

PDB 3DF0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains.
Moldoveanu, T., Gehring, K., Green, D.R.
Nature