CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family NEDD8-activating enzyme E1 catalytic subunit, putative

Enzyme Information

6.2.1.-
Acid--thiol ligases.
based on mapping to UniProt Q8TBC4

UniProtKB Entries (1)

Q15843
NEDD8_HUMAN
Homo sapiens
NEDD8

PDB Structure

PDB 3DBL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.
Souphron, J., Waddell, M.B., Paydar, A., Tokgoz-Gromley, Z., Roussel, M.F., Schulman, B.A.
Biochemistry