CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.450.40
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt P52731
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

P52731
PDE6C_CHICK
Gallus gallus
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

PDB Structure

PDB 3DBA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change.
Martinez, S.E., Heikaus, C.C., Klevit, R.E., Beavo, J.A.
J.Biol.Chem.