CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.300.30
Functional Family Acyl-coenzyme A synthetase ACSM5, mitochondrial

Enzyme Information

6.2.1.2
Medium-chain acyl-CoA ligase.
based on mapping to UniProt Q08AH3
ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium- chain acyl-CoA.
-!- Acts on fatty acids from C(4) to C(11) and on the corresponding 3-hydroxy and 2,3- or 3,4-unsaturated acids. -!- The enzyme from the bacterium Pseudomonas putida also acts on 4-oxo and 4-hydroxy derivatives.

UniProtKB Entries (1)

Q08AH3
ACS2A_HUMAN
Homo sapiens
Acyl-coenzyme A synthetase ACSM2A, mitochondrial

PDB Structure

PDB 3DAY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
Kochan, G., Pilka, E.S., von Delft, F., Oppermann, U., Yue, W.W.
J.Mol.Biol.