CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Dipeptidyl peptidase 4

Enzyme Information

3.4.14.5
Dipeptidyl-peptidase IV.
based on mapping to UniProt P27487
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.

UniProtKB Entries (1)

P27487
DPP4_HUMAN
Homo sapiens
Dipeptidyl peptidase 4

PDB Structure

PDB 3D4L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.
Liang, G.B., Qian, X., Biftu, T., Singh, S., Gao, Y.D., Scapin, G., Patel, S., Leiting, B., Patel, R., Wu, J., Zhang, X., Thornberry, N.A., Weber, A.E.
Bioorg.Med.Chem.Lett.