1 keywords

CATH Domain 3d3lA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.10 Roll
Topology 3.10.450 Nuclear Transport Factor 2; Chain: A,
Homologous Superfamily 3.10.450.60  

Domain Context

CATH Clusters

Superfamily 3.10.450.60
Functional Family

Enzyme Information

3.3.2.-
Ether hydrolases.
based on mapping to UniProt P18054
1.13.11.31
Arachidonate 12-lipoxygenase.
based on mapping to UniProt P18054
Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate.
-!- The product is rapidly reduced to the corresponding 12S-hydroxy compound.

UniProtKB Entries (1)

P18054
LOX12_HUMAN
Homo sapiens
Arachidonate 12-lipoxygenase, 12S-type

PDB Structure

PDB 3D3L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the lipoxygenase domain of human Arachidonate 12-lipoxygenase, 12S-type.
Tresaugues, L., Moche, M., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Herman, M.D., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Lehtio, L., Nilsson, M.E., Nyman, T., Olesen, K., Persson, C., Sagemark, J., Schueler, H., Svensson, L., Thorsell, A.G., Van Den Berg, S., Welin, M., Weigelt, J., Wikstrom, M., Nordlund, P.
To be Published