CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.465.10
Functional Family

Enzyme Information

1.21.3.3
Reticuline oxidase.
based on mapping to UniProt P30986
(S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2).
-!- Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge ('berberine bridge') of (S)- tetrahydroprotoberberines. -!- The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants. -!- Formerly EC 1.5.3.9.

UniProtKB Entries (1)

P30986
RETO_ESCCA
Eschscholzia californica
Reticuline oxidase

PDB Structure

PDB 3D2H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A concerted mechanism for berberine bridge enzyme
Winkler, A., Lyskowski, A., Riedl, S., Puhl, M., Kutchan, T.M., Macheroux, P., Gruber, K.
Nat.Chem.Biol.