CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P31751
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P31751
AKT2_HUMAN
Homo sapiens
RAC-beta serine/threonine-protein kinase

PDB Structure

PDB 3D0E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
Heerding, D.A., Rhodes, N., Leber, J.D., Clark, T.J., Keenan, R.M., Lafrance, L.V., Li, M., Safonov, I.G., Takata, D.T., Venslavsky, J.W., Yamashita, D.S., Choudhry, A.E., Copeland, R.A., Lai, Z., Schaber, M.D., Tummino, P.J., Strum, S.L., Wood, E.R., Duckett, D.R., Eberwein, D., Knick, V.B., Lansing, T.J., McConnell, R.T., Zhang, S., Minthorn, E.A., Concha, N.O., Warren, G.L., Kumar, R.
J.Med.Chem.