CATH Classification

Domain Context

CATH Clusters

Superfamily Malate synthase, domain III
Functional Family Malate synthase

Enzyme Information

2.3.3.9
Malate synthase.
based on mapping to UniProt P08997
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.
-!- The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. -!- Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2). -!- Formerly EC 4.1.3.2.

UniProtKB Entries (1)

P08997
MASY_ECOLI
Escherichia coli K-12
Malate synthase A

PDB Structure

PDB 3CV2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Atomic resolution structures of Escherichia coli and Bacillus anthracis malate synthase A: comparison with isoform G and implications for structure-based drug discovery
Lohman, J.R., Olson, A.C., Remington, S.J.
Protein Sci.