CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain
Functional Family [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

Enzyme Information

2.7.11.2
[Pyruvate dehydrogenase (acetyl-transferring)] kinase.
based on mapping to UniProt Q64536
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.
-!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. -!- Phosphorylation inactivates EC 1.2.4.1. -!- Formerly EC 2.7.1.99.

UniProtKB Entries (2)

Q64536
PDK2_RAT
Rattus norvegicus
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
P10515
ODP2_HUMAN
Homo sapiens
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

PDB Structure

PDB 3CRK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and functional insights into the molecular mechanisms responsible for the regulation of pyruvate dehydrogenase kinase 2.
Green, T., Grigorian, A., Klyuyeva, A., Tuganova, A., Luo, M., Popov, K.M.
J.Biol.Chem.