CATH Classification

Domain Context

CATH Clusters

Superfamily RNA polymerase alpha subunit dimerisation domain
Functional Family DNA-directed RNA polymerase subunit B

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P08518
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P27999
RPB9_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase II subunit RPB9

PDB Structure

PDB 3CQZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin.
Kaplan, C.D., Larsson, K.M., Kornberg, R.D.
Mol.Cell