CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P31749
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P49841
GSK3B_HUMAN
Homo sapiens
Glycogen synthase kinase-3 beta

PDB Structure

PDB 3CQW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and structure based optimization of novel Akt inhibitors
Lippa, B., Pan, G., Corbett, M., Li, C., Kauffman, G.S., Pandit, J., Robinson, S., Wei, L., Kozina, E., Marr, E.S., Borzillo, G., Knauth, E., Barbacci-Tobin, E.G., Vincent, P., Troutman, M., Baker, D., Rajamohan, F., Kakar, S., Clark, T., Morris, J.
Bioorg.Med.Chem.Lett.