CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P62593
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P62593
BLAT_ECOLX
Escherichia coli
Beta-lactamase TEM

PDB Structure

PDB 3CMZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase
Marciano, D.C., Pennington, J.M., Wang, X., Wang, J., Chen, Y., Thomas, V.L., Shoichet, B.K., Palzkill, T.
J.Mol.Biol.