CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt Q27793
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt Q27793
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

Q27793
DRTS_TRYCR
Trypanosoma cruzi
Bifunctional dihydrofolate reductase-thymidylate synthase

PDB Structure

PDB 3CLB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.
Schormann, N., Senkovich, O., Walker, K., Wright, D.L., Anderson, A.C., Rosowsky, A., Ananthan, S., Shinkre, B., Velu, S., Chattopadhyay, D.
Proteins