CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family | Fumarate reductase flavoprotein subunit |
Enzyme Information
| 1.3.5.4 |
Fumarate reductase (quinol).
based on mapping to UniProt P00363
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.
|
UniProtKB Entries (1)
| P00363 |
FRDA_ECOLI
Escherichia coli K-12
Fumarate reductase flavoprotein subunit
|
PDB Structure
| PDB | 3CIR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
A threonine on the active site loop controls transition state formation in Escherichia coli respiratory complex II.
J.Biol.Chem.
|