CATH Classification

Domain Context

CATH Clusters

Superfamily Metalloproteases ("zincins"), catalytic domain like
Functional Family Botulinum neurotoxin type A

Enzyme Information

3.4.24.69
Bontoxilysin.
based on mapping to UniProt P0DPI1
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.

UniProtKB Entries (1)

P0DPI1
BXA1_CLOBH
Clostridium botulinum A str. Hall
Botulinum neurotoxin type A

PDB Structure

PDB 3C89
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure- and Substrate-based Inhibitor Design for Clostridium botulinum Neurotoxin Serotype A
Kumaran, D., Rawat, R., Ludivico, M.L., Ahmed, S.A., Swaminathan, S.
J.Biol.Chem.