CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family spermine synthase

Enzyme Information

2.5.1.22
Spermine synthase.
based on mapping to UniProt P52788
S-adenosyl 3-(methylthio)propylamine + spermidine = S-methyl- 5'-thioadenosine + spermine.
-!- The enzyme from mammalia is highly specific for spermidine, cf. EC 2.5.1.16 and EC 2.5.1.23.

UniProtKB Entries (1)

P52788
SPSY_HUMAN
Homo sapiens
Spermine synthase

PDB Structure

PDB 3C6K
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism.
Wu, H., Min, J., Zeng, H., McCloskey, D.E., Ikeguchi, Y., Loppnau, P., Michael, A.J., Pegg, A.E., Plotnikov, A.N.
J.Biol.Chem.