CATH Classification

Domain Context

CATH Clusters

Superfamily CofD-like domains
Functional Family

Enzyme Information

2.7.8.28
2-phospho-L-lactate transferase.
based on mapping to UniProt Q8PVT6
(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5- deazariboflavin = guanosine 5'-phosphate + coenzyme F420-0.
-!- This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor found in all methanogenic archaea, as well as some eubacteria.

UniProtKB Entries (1)

Q8PVT6
COFD_METMA
Methanosarcina mazei Go1
2-phospho-L-lactate transferase

PDB Structure

PDB 3C3D
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular insights into the biosynthesis of the f420 coenzyme.
Forouhar, F., Abashidze, M., Xu, H., Grochowski, L.L., Seetharaman, J., Hussain, M., Kuzin, A., Chen, Y., Zhou, W., Xiao, R., Acton, T.B., Montelione, G.T., Galinier, A., White, R.H., Tong, L.
J.Biol.Chem.