CATH Classification

Domain Context

CATH Clusters

Superfamily Quinolinate phosphoribosyl transferase, N-terminal domain
Functional Family Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Enzyme Information

2.4.2.19
Nicotinate-nucleotide diphosphorylase (carboxylating).
based on mapping to UniProt P43619
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3- dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- The reaction is catalyzed in the opposite direction. -!- Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD(+) biosynthesis enzyme shared by both eukaryotes and prokaryotes.

UniProtKB Entries (1)

P43619
NADC_YEAST
Saccharomyces cerevisiae S288C
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

PDB Structure

PDB 3C2R
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Comprehensive X-ray Structural Studies of the Quinolinate Phosphoribosyl Transferase (BNA6) from Saccharomyces cerevisiae.
di Luccio, E., Wilson, D.K.
Biochemistry