CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA integrity scanning protein DisA

Enzyme Information

2.7.7.85
Diadenylate cyclase.
based on mapping to UniProt Q9WY43
2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate.
-!- Cyclic di-3',5'-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signaling molecule. -!- The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host's cytosol, where it triggers a cytosolic pathway of innate immunity.

UniProtKB Entries (1)

Q9WY43
DISA_THEMA
Thermotoga maritima MSB8
DNA integrity scanning protein DisA

PDB Structure

PDB 3C23
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates
Witte, G., Hartung, S., Buttner, K., Hopfner, K.P.
Mol.Cell