CATH Classification

Domain Context

CATH Clusters

Superfamily Acetylglutamate kinase-like
Functional Family Bifunctional aspartokinase/homoserine dehydrogenase

Enzyme Information

2.7.2.4
Aspartate kinase.
based on mapping to UniProt Q57991
ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
-!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 1.1.1.3. -!- This is also the case for two of the four isoenzymes in Arabidopsis thaliana. -!- The equilibrium constant strongly favors the reaction from right to left, i.e. the non-physiological direction of reaction.

UniProtKB Entries (1)

Q57991
AK_METJA
Methanocaldococcus jannaschii DSM 2661
Probable aspartokinase

PDB Structure

PDB 3C20
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Structural Basis for Allosteric Inhibition of a Threonine-sensitive Aspartokinase.
Liu, X., Pavlovsky, A.G., Viola, R.E.
J.Biol.Chem.