CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Catechol O-methyltransferase

Enzyme Information

2.1.1.6
Catechol O-methyltransferase.
based on mapping to UniProt P21964
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
-!- The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.

UniProtKB Entries (1)

P21964
COMT_HUMAN
Homo sapiens
Catechol O-methyltransferase

PDB Structure

PDB 3BWY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of human 108V and 108M catechol O-methyltransferase.
Rutherford, K., Le Trong, I., Stenkamp, R.E., Parson, W.W.
J.Mol.Biol.