CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P06213
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (2)

P81122
IRS2_MOUSE
Mus musculus
Insulin receptor substrate 2
P06213
INSR_HUMAN
Homo sapiens
Insulin receptor

PDB Structure

PDB 3BU6
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.
Wu, J., Tseng, Y.D., Xu, C.F., Neubert, T.A., White, M.F., Hubbard, S.R.
Nat.Struct.Mol.Biol.