CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.50 | OB fold (Dihydrolipoamide Acetyltransferase, E2P) |
|
2.40.50.1070 |
Domain Context
CATH Clusters
| Superfamily | 2.40.50.1070 |
| Functional Family | tRNA/tmRNA (uracil-C(5))-methyltransferase |
Enzyme Information
| 2.1.1.35 |
tRNA (uracil(54)-C(5))-methyltransferase.
based on mapping to UniProt P23003
S-adenosyl-L-methionine + uracil(54) in tRNA = S-adenosyl-L-homocysteine + 5-methyluracil(54) in tRNA.
-!- Unlike this enzyme, EC 2.1.1.74 uses 5,10-methylenetetrahydrofolate and FADH(2) to supply the atoms for methylation of U54.
|
| 2.1.1.- |
Methyltransferases.
based on mapping to UniProt P23003
|
UniProtKB Entries (1)
| P23003 |
TRMA_ECOLI
Escherichia coli K-12
TRNA/tmRNA (uracil-C(5))-methyltransferase
|
PDB Structure
| PDB | 3BT7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases.
Proc.Natl.Acad.Sci.Usa
|