CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family tRNA/tmRNA (uracil-C(5))-methyltransferase

Enzyme Information

2.1.1.35
tRNA (uracil(54)-C(5))-methyltransferase.
based on mapping to UniProt P23003
S-adenosyl-L-methionine + uracil(54) in tRNA = S-adenosyl-L-homocysteine + 5-methyluracil(54) in tRNA.
-!- Unlike this enzyme, EC 2.1.1.74 uses 5,10-methylenetetrahydrofolate and FADH(2) to supply the atoms for methylation of U54.
2.1.1.-
Methyltransferases.
based on mapping to UniProt P23003

UniProtKB Entries (1)

P23003
TRMA_ECOLI
Escherichia coli K-12
TRNA/tmRNA (uracil-C(5))-methyltransferase

PDB Structure

PDB 3BT7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases.
Alian, A., Lee, T.T., Griner, S.L., Stroud, R.M., Finer-Moore, J.
Proc.Natl.Acad.Sci.Usa