CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family

Enzyme Information

4.2.3.9
Aristolochene synthase.
based on mapping to UniProt Q9UR08
(2E,6E)-farnesyl diphosphate = aristolochene + diphosphate.
-!- The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene. -!- While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC 4.2.3.23). -!- Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi. -!- Formerly EC 2.5.1.40 and EC 4.1.99.7.

UniProtKB Entries (1)

Q9UR08
ARIS_ASPTE
Aspergillus terreus
Aristolochene synthase

PDB Structure

PDB 3BNY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis
Shishova, E.Y., Yu, F., Miller, D.J., Faraldos, J.A., Zhao, Y., Coates, R.M., Allemann, R.K., Cane, D.E., Christianson, D.W.
J.Biol.Chem.