CATH Classification

Domain Context

CATH Clusters

Superfamily Lipoxygenase-1; Domain 5
Functional Family Lipoxygenase 3, putative, expressed

Enzyme Information

1.13.11.12
Linoleate 13S-lipoxygenase.
based on mapping to UniProt P08170
(1) Linoleate + O(2) = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate. (2) Alpha-linolenate + O(2) = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca- 9,11,15-trienoate.
-!- A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(13) position with (S)- configuration. -!- This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. -!- EC 1.13.11.58 catalyzes a similar reaction at the second available position of these fatty acids. -!- Formerly EC 1.13.1.13 and EC 1.99.2.1.

UniProtKB Entries (1)

P08170
LOX1_SOYBN
Glycine max
Seed linoleate 13S-lipoxygenase-1

PDB Structure

PDB 3BNE
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1.
Meyer, M.P., Tomchick, D.R., Klinman, J.P.
Proc.Natl.Acad.Sci.Usa