CATH Classification

Domain Context

CATH Clusters

Superfamily HIT-like
Functional Family m7GpppX diphosphatase

Enzyme Information

3.6.1.59
5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
based on mapping to UniProt Q96C86
A 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA].
-!- The enzyme removes (decaps) the N(7)-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides. -!- Decapping is an important process in the control of eukaryotic mRNA degradation. -!- The enzyme functions to clear the cell of cap structure following decay of the RNA body. -!- The nematode enzyme can also decap triply methylated substrates, 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-[mRNA]. -!- Formerly EC 3.6.1.30.

UniProtKB Entries (1)

Q96C86
DCPS_HUMAN
Homo sapiens
M7GpppX diphosphatase

PDB Structure

PDB 3BL7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
DcpS as a therapeutic target for spinal muscular atrophy.
Singh, J., Salcius, M., Liu, S.W., Staker, B.L., Mishra, R., Thurmond, J., Michaud, G., Mattoon, D.R., Printen, J., Christensen, J., Bjornsson, J.M., Pollok, B.A., Kiledjian, M., Stewart, L., Jarecki, J., Gurney, M.E.
Acs Chem.Biol.