CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Carbonyl reductase [NADPH] 1

Enzyme Information

1.1.1.189
Prostaglandin-E(2) 9-reductase.
based on mapping to UniProt P16152
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
-!- Reduces prostaglandin E(2) to prostaglandin F(2)-alpha. -!- A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds. -!- May be identical with EC 1.1.1.197.
1.1.1.197
15-hydroxyprostaglandin dehydrogenase (NADP(+)).
based on mapping to UniProt P16152
(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)- 11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.
-!- Acts on prostaglandins E(2), F(2)-alpha and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.141 and EC 1.1.1.196). -!- May be identical with EC 1.1.1.189.
1.1.1.184
Carbonyl reductase (NADPH).
based on mapping to UniProt P16152
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
-!- Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol. -!- Si-specific with respect to NADPH (cf. EC 1.1.1.2).

UniProtKB Entries (1)

P16152
CBR1_HUMAN
Homo sapiens
Carbonyl reductase [NADPH] 1

PDB Structure

PDB 3BHM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Human carbonyl reductase 1 is an s-nitrosoglutathione reductase
Bateman, R.L., Rauh, D., Tavshanjian, B., Shokat, K.M.
J.Biol.Chem.