CATH Classification

Domain Context

CATH Clusters

Superfamily Thrombin light chain domain
Functional Family

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin

PDB Structure

PDB 3BEI
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
Structural identification of the pathway of long-range communication in an allosteric enzyme.
Gandhi, P.S., Chen, Z., Mathews, F.S., Di Cera, E.
Proc.Natl.Acad.Sci.Usa